Title of article :
The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study
Author/Authors :
Hossein-khannazer, Nikoo Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Kazem Arki, Mandana Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Keramatinia, Aliasghar Department of Social Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rezaei-Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines and
chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT)
as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits
the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune
responses and induces the production of growth factors.
Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the
treatment of MS. Such keywords as “low-level laser therapy”, “photobiomodulation” and “multiple
sclerosis” were used to find studies related to laser therapy in MS in Google scholar, PubMed and
Medline databases.
Results: LLLT reduced the inflammatory immune cells and mediators. It also enhanced the
regeneration of neurons.
Conclusion: Investigations showed that besides current treatment strategies, LLLT could be a
promising therapeutic approach for the treatment of MS.
Keywords :
Low-level laser therapy (LLLT) , Multiple sclerosis (MS) , Photobiomodulation , Laser therapy , Autoimmune disease
Journal title :
Journal of Lasers in Medical Sciences
