Author/Authors :
Antychin, T Department of Pulmonology - Antwerp University Hospital - Edegem, Belgium , Zarowski, J.A Department of Pulmonology - Antwerp University Hospital - Edegem, Belgium , Verplancke, V Department of Pulmonology - Antwerp University Hospital - Edegem, Belgium , Hendriks, J. M.H. Department of Thoracic and Vascular Surgery - Antwerp University Hospital - Edegem, Belgium , Yogeswaran, S.K Department of Thoracic and Vascular Surgery - Antwerp University Hospital - Edegem, Belgium , Lauwers, P Department of Thoracic and Vascular Surgery - Antwerp University Hospital - Edegem, Belgium , Lamote, K Department of Internal Medicine - Ghent University - Ghent, Belgium , Kwakkel-van Erp, J. M. Department of Pulmonology - Antwerp University Hospital - Edegem, Belgium
Abstract :
Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ
transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological
symptoms such as headache, tremor and seizures. In this case report, we describe a patient who
developed severe motor and sensory neuron dysfunction related to CNIs after bilateral lung transplantation,
which resolved after halting CNI and switching to a mammalian Target of Rapamycin-inhibitor.
Keywords :
Reversible neuropathy , Lung transplantation , mTOR-inhibitor , Calcineurin inhibitors
