Title of article :
Incidence of acute kidney injury in bone marrow transplant patients; investigation of consequences within one to three years
Author/Authors :
Aref, Asieh Department of Internal Medicine - Chronic Renal Failure Research Center - Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Ira , Maleknia, Mohsen Thalassemia and Hemoglobinopathy Research Center - Health Research Institute - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Nasrollahi, Alireza Department of Nephrology - Taleghani Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hajifathali, Abbas Department of Medical Genetics - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mehdizadeh, Mahshid Hematopoietic Stem Cell Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Kazemi, Hashem Thalassemia and Hemoglobinopathy Research Center - Health Research Institute - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Ghadiani, Mohammad Hassan Urology and Nephrology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Previous studies have demonstrated that acute kidney injury (AKI) is a serious
complication following hematopoietic stem cell transplantation (HSCT). The incidence of AKI in
association with HSCT varies considerably because of several definitions for AKI.
Objectives: In this study, we determined the rate of AKI after bone marrow transplantation (BMT)
and its effects on patients’ outcomes according to modern definitions of AKI to conclude whether
all these criteria can be useful for predicting AKI occurrence after BMT or not.
Patients and Methods: We conducted a retrospective study of 271 patients undergoing HSCT, and
after obtaining written informed consent from all patients, the required information was reviewed.
AKI was defined according to RIFLE, KDIGO, and AKIN criteria. Renal function was assessed by
calculating creatinine clearance, urine output, and estimated glomerular filtration rate (eGFR),
determined through the MDRD equation.
Results: Allogeneic and autologous transplantations were performed on 38 (14.02%) and 233
(85.97%) patients, respectively. According to the RIFLE criteria, 96 patients (35.42%) suffered
from AKI, and based on AKIN, and KDIGO criteria, 101 patients (37.26%) were afflicted with it
after BMT. The one-year mortality rate in allogeneic transplant patients with a history of AKI was
30.43% and 53.33% in patients without a history of AKI. The three-year mortality rate in allogeneic
transplant patients with and without a history of AKI was 52.17% and 73.33% respectively,
which showed no statistically significant difference. The three-year mortality rate in autologous
transplant patients with and without a history of AKI was 60.27% and 22.5%, respectively.
Conclusion: The one-year and three-year mortality rates, survival of patients, and AKI’s diagnosis
were similar in all three criteria. Therefore, all these criteria can be useful for the prediction of AKI
occurrence after BMT.
Keywords :
Acute kidney injury , Bone marrow transplantation , Allogeneic , Autologous
Journal title :
Journal of Renal Injury Prevention
