Author/Authors :
Abbasi, Saeed Isfahan University of Medical Sciences - Isfahan, Iran , Naderi, Zohre Department of Pulmonology - Isfahan University of Medical Sciences - Isfahan, Iran , Amra, Babak Isfahan University of Medical Sciences - Isfahan, Iran , Atapour, Abdolamir Isfahan University of Medical Sciences - Isfahan, Iran , Dadkhahi, Amir Department of Pulmonology - Isfahan University of Medical Sciences - Isfahan, Iran , Eslami, Mohammad Javad School of Medicine - Isfahan University of Medical Sciences - Isfahan, Iran , Hajian, Mohammad Reza School of Medicine - Isfahan University of Medical Sciences - Isfahan, Iran , Hashemi, Marzieh Department of Pulmonology - Amin Hospital - Isfahan University of Medical Sciences - Isfahan, Iran , Hashemi, Taghi Isfahan University of Medical Sciences - Isfahan, Iran , Iraj, Bijan Department of Internal Medicine - Endocrine and Metabolism Research Center - School of Medicine - Isfahan University of Medical Sciences - Isfahan, Iran , Khorvash, Farzin Isfahan University of Medical Sciences - Isfahan, Iran , Madadi, Samane Khatamolanbia Natanz Regional Hospital - Isfahan University of Medical Sciences - Isfahan, Iran , Mahjoubi Pour, Hossein Department of Anesthesiology and Critical Care Medicine - Critical care Research Center - Medical School - Isfahan University of Medical Sciences - Isfahan, Iran , Mansourian, Marjan Department of Epidemiology and Biostatics - School of Health - Isfahan University of Medical Sciences - Isfahan, Iran , Rezvani, Majid Department of Neurosurgery - Neuroscience Research Center - School of Medicine - Al Zahra Hospital - Isfahan University of Medical Sciences - Isfahan, Iran , Sami, Ramin Department of Internal Medicine - School of Medicine - Isfahan University of Medical Sciences - Isfahan, Iran , Soltaninejad, Forough Isfahan University of Medical Sciences - Isfahan, Iran , Shahidi, Shahrzad Isfahan University of Medical Sciences - Isfahan, Iran , Vahdat, Sahar Isfahan University of Medical Sciences - Isfahan, Iran , Zamani, Zahra Isfahan University of Medical Sciences - Isfahan, Iran , Moeinzadeh, Firouzeh Isfahan University of Medical Sciences - Isfahan, Iran
Abstract :
Background: The new coronavirus outbreak quickly filled hospital beds and stunned the world. Intensive care is required for 5% of
patients, and the mortality rate for critically ill patients is 49%. The “cytokine storm” is considered as the main cause of pathogenesis
for coronavirus disease‑19 (COVID-19)‑related respiratory failure, hemoperfusion may be a modality for treatment of disease.
Materials and Methods: Thirty-seven an patients with positive real‑time polymerase chain reaction for SARStions2 in an upper
respiratory tract sample or typical chest computed tomography lesion were eligible for this case–control study. Patients meeting the
criteria for hemoperfusion including clinical and laboratory indices, were evaluated for outcomes such as hospitalization length
and mortality. Patients were divided into three groups, i.e., patients who received hemoperfusion without a need for mechanical
ventilation (MV), patients who received hemoperfusion before MV, and patients who received hemoperfusion after MV. Results: Among
37 patients with COVID-19 respiratory failure, 32% were female with a mean age of 55.54 (standard deviation 14.1) years. There was no
statistically significant difference between the three groups in terms of length of hospital stay and intensive care unit (ICU) stay (P-tayns:
0.593 and 0.243, respectively, confidence interval [CI]: 95%). Heart rate, respiratory rate, PaO2/FIO2, high‑sensitivity C‑reactive protein,
and ferritin significantly improved after the application of hemoperfusion in all groups (P < 0.05, CI: 95%). Conclusion : It seems that
applying hemoperfusion in the inflammatory phase of the disease, especially before the intubation, reduce the need for MV. However,
hemoperfusion does not have any impacts on the duration of hospital and ICU stay.
