A study of the Cisplatin effect on testis of Infected mice with Echinococcus granulosus

In the present work, 25 male Balb/c mice have been used ( 5 mice are not infected with Echinococcus granulosus and untreated with cisplatin used as a control group),(10 infected with Echinococcus granulosus untreated mice) and (10 infected with Echinococcus granulosus treated with Cisplatin 100 mg/m2 weekly for three weeks),these 20 mice considered as test group. the histopathological study of testis specimen show that the infected untreated groups have no histopathological changes in comparism to the control group, while the infected and treated group shows significant histopathological changes such as that the seminiferrous tubules destroyed completely, there is loss of many seminiferrous tubules, extensive necrosis in rete testis and the cells of the efferent duct are flat and attenuated arrangement singly or in clusters with round nuclei.