Spectrophotometric Determination of Ranitidine-HCl in Pure Form and Pharmaceutical Formulations with Metol and potassium hexacyanoferrate (Ill)

A simple, sensitive and accurate spectrophotometric method of determination of Ranitidine-HCl (RNH) in pure form and its pharmaceutical formulation. Was used in this studyThe method is based on the formation of (RNH) complex. The reaction between the Ranitidine-HCl with the mixture of metol and potassium hexacyanoferrate (Ill) was evaluate metol ( Nmethyl - p - aminophenosulphate ) for the spectrophotometric determination of the Ranitidine - HCl . The maximum absorbance of the colored complex occurred at X = 540nm. Reaction conditions have been optimized to obtain (RNH) complex of high sensitivity and longer stability. Under optimum conditions the absorbance of the (RNH) complex where found to increase linearly with the increase in concentration of the Ranitidine-HCl which corroborated with correlation coefficient value. Of 0.09995with concetration ranges of(2-90) ^g /ml relative standard deviation and relative error of prediction for drug were lower . The proposed method was successfully applied to determine of the selected Ranitidine-HCl in pure form and pharmaceutical formulations with good precision and accuracy compared to standard method as revealed by t- and F- values , the results obtained agree well with the labeled contents.