Author/Authors :
Ainurofiq, Ahmad Department of Pharmacy - Sebelas Maret University, Ir. Sutami, Surakarta, Indonesia , Sarono Putro, David Department of Pharmacy - Sebelas Maret University, Ir. Sutami, Surakarta, Indonesia , Aqila Ramadhani, Dhea Department of Pharmacy - Sebelas Maret University, Ir. Sutami, Surakarta, Indonesia , Mahendra Putra, Gemala Department of Pharmacy - Sebelas Maret University, Ir. Sutami, Surakarta, Indonesia , Da Costa Do Espirito Santo, Laura Department of Pharmacy - Sebelas Maret University, Ir. Sutami, Surakarta, Indonesia
Abstract :
One of the most important parameters in pharmacy is drug solubility. Solubility affects the efficacy of
a drug. Drug solubility has an important role in determining the concentration of a drug to achieve the
necessary pharmacological response, as all drugs absorbed by the body must be in the form of a solution.
Drug solubility is quite a common issue and affects the bioavailability of a drug in the body. Drugs with
low solubility are poorly absorbed, resulting in poor bioavailability. Many methods have been developed
for increasing the solubility of a drug. In this review, we will describe possible efforts for improving the
solubility of a drug, e.g., reducing particle size, surfactants, the use of nanosuspension technology, solid
dispersion, salt formation, pH adjustment, hydrotropy, cocrystal, amorphous compound formation, and
inclusion complexes. The main objective of this review was to focus on efforts that can increase the
solubility of a drug to obtain good drug efficacy.
