Title of article :
Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran
Author/Authors :
Ghaffari ، Hadi Department of Bacteriology and Virology - Faculty of Medicine - Semnan University of Medical Sciences , Tavakoli ، Ahmad Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases - Iran University of Medical Sciences , Faranoush ، Mohammad Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism - Iran University of Medical Sciences , Naderi ، Ali Mahak Pediatric Cancer Treatment and Research Center , Kiani ، Jalal Department of Medical Virology - Faculty of Medicine - Iran University of Medical Sciences , Sadeghipour ، Alireza Department of Pathology - Hazrat-e-Rasoul Akram Hospital - Iran University of Medical Sciences , Javanmard ، Davod Infectious Diseases Research Center - Birjand University of Medical Sciences , Farahmand ، Mohammad Department of Virology - School of Public Health - Tehran University of Medical Sciences , Ghorbani ، Saied Department of Medical Virology - Faculty of Medicine - Iran University of Medical Sciences , Sedaghati ، Farnoush Department of Pathology - Faculty of Medicine - Iran University of Medical Sciences , Monavari ، Hamidreza Department of Medical Virology - Faculty of Medicine - Iran University of Medical Sciences
Abstract :
Background: Glioblastoma multiforme is the most invasive and lethal form of brain cancer with unclear etiology. Our study aimed to investigate the molecular prevalence of HCMV and EBV infections in patients with GBM. Methods: This case-control study was conducted on 42 FFPE brain tumor samples from GBM patients and 42 brain autopsies from subjects without neurological disorders. The presence of EBV and HCMV DNA was determined, using PCR and nested-PCR assays, respectively. Results: HCMV DNA was detected in 3 out of 42 (7.1%) of GBM samples and was absent from the control group (p = 0.07). Importantly, EBV DNA was detected in 9 out of 42 (21.4%) brain tissue specimens of GBM subjects, but again in none of the control group (p = 0.001). Conclusion: Our findings indicate that infection with EBV is associated with GBM
Keywords :
Brain tumor , Epstein , Barr virus , Glioblastoma , Human cytomegalovirus
Journal title :
Iranian Biomedical Journal(IBJ)
Journal title :
Iranian Biomedical Journal(IBJ)
