Title of article :
Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients
Author/Authors :
Aghabozorg Afjeh ، Sara Sadat Department of Medical Genetics - Shahid Beheshti University of Medical Sciences , Shams ، Jamal Behavioral Research Center - Shahid Beheshti University of Medical Sciences , Hamednia ، Safar Department of Psychiatry - Urmia University of Medical Sciences , Boshehri ، Behzad Department of Forensic Medicine and Toxicology - Urmia University of Medical Sciences , Amini ، Asmaolhosna Sara Medical Genetics Laboratory , Omrani ، Amin Faculty of Medicine - Tehran University of Medical Sciences , Omrani ، Davood Department of Medical Genetics - Urogenital Stem Cell Research Center - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Lithium is a therapeutic option for the treatment of the acute phase of the bipolar disorder and long-term management of this disorder. However, it is estimated that 10 to 60% of patients do not properly response to this medication. Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar patients using ARMS-PCR. Results: Results of this study showed a significant association of this polymorphism with response to lithium. The A allele was more frequent in the responder than the non-responder group and also in the semi- responder group compared to the non-responder group in the codominant model of analysis. AA and AG genotypes were more frequent in both the responder and semi-responder groups compared to the non-responder group in dominant model of analysis. Conclusion: Based on the findings of the current study, the rs10792421 variant of MARK2 gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population. DOI: 10.52547/ibj.26.2.110
Keywords :
Biomarkers , Bipolar , Lithium , Genotyping
Journal title :
Iranian Biomedical Journal(IBJ)
Journal title :
Iranian Biomedical Journal(IBJ)
