Author/Authors :
Shiro ، Yukiko Department of Physical Therapy - Faculty of Rehabilitation Sciences - Nagoya Gakuin University , Arai ، Young-Chang Multidisciplinary Pain Center, School of Medicine - Aichi Medical University , Ikemoto ، Tatsunori Department of Orthopedics - School of Medicine - Aichi Medical University , Ushida ، Takahiro Multidisciplinary Pain Center, School of Medicine, Institute of Physical Fitness, Sports Medicine and Rehabilitation - Aichi Medical University
Abstract :
The gut microbiota (GM) plays an important role in gutbrain communication, and the ‘gutbrain axis’ has attracted much attention as a factor influencing human host health. We previously reported that pain perception may be associated with GM composition in males. The aim of this study was to investigate the relationship between GM composition and pain perception among 42 healthy female university students in Japan. Pain perception was evaluated by pressure pain threshold (PPT), current perception threshold (CPT), temporal summation of pain (TSP), conditioned pain modulation (CPM), and a questionnaire on psychological state. CPT was stimulated at 5, 250, and 2,000 Hz, which reflected the thresholds of the C, Aδ, and Aβ fibers, respectively. Also, GM composition was estimated using 16S rRNA analysis. The lower alpha diversity was associated with, the lower PPT (rs = 0.330, P 0.05) and CPT of 2000 Hz (re = 0.339, P 0.05). Furthermore, alpha diversity was identified as an explanatory variable for PPT (β = 0.424, P 0.01) and TSP (β = 0.317, P 0.05), alpha diversity and state anxiety for CPT of 2000 Hz (β = 0.321, P 0.05), and state anxiety for CPT of 250 Hz (β = 0.320, P 0.05). However, there was no relationship between the rate of major phylum and pain perception.
