Title of article :
Fatal pulmonary Scedosporium aurantiacum infection in a patient after near-drowning: A case report
Author/Authors :
Ghasemian ، Roya Antimicrobial Resistance Research Center, Communicable Diseases Institute - Mazandaran University of Medical Sciences , Bandegani ، Azadeh Student Research Committee - Mazandaran University of Medical Sciences , Kermani ، Firoozeh Department of Medical Mycology - School of Medicine, Invasive Fungi Research Centre (IFRC) - Mazandaran University of Medical Sciences , Faeli ، Leila Student Research Committee - Mazandaran University of Medical Sciences , Roohi ، Behrad Student Research Committee - Mazandaran University of Medical Sciences , Yosefi Abdolmaleki ، Elham Department of Internal Medicine - School of Medicine - Mazandaran University of Medical Sciences , Hedayati ، Mohammad T. Department of Medical Mycology - Invasive Fungi Research Center, Communicable Diseases Institute, School of Medicine - Mazandaran University of Medical Sciences , Roilides ، Emmanuel Infectious Diseases Section, 3rd Department of Pediatrics - Faculty of Medicine, School of Health Sciences - Aristotle University , Shokohi ، Tahereh Department of Medical Mycology - Invasive Fungi Research Center, Communicable Diseases Institute, School of Medicine - Mazandaran University of Medical Sciences
Abstract :
Background and Purpose: Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts. Case report: Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal. Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were 16 μg/ml, and 8 μg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 μg/ml. Conclusion: This report, as the first case of pulmonary scedosporiosis after near-drowning in Iran, highlights the importance of high suspicion in near-drowning victims, prompt identification of Scedosporium spp., and early initiation of appropriate antifungal therapy.
Keywords :
Antifungal susceptibility test , Amphotericin B , Invasive pulmonary infection , Near , drowning , Scedosporium aurantiacum , Voriconazole
Journal title :
Current Medical Mycology
Journal title :
Current Medical Mycology
