Title of article :
COVID-19 in Chronic Granulomatosis Disease: A Case Report
Author/Authors :
Esmaeilzadeh ، Hossein Department of Allergy and Clinical Immunology - Allergy Research Center, Namazi Hospital - Shiraz University of Medical Sciences , Dehghani ، Sina Department of Pediatric - School of Medicine - Shiraz University of Medical Sciences , Shahhoseini ، Babak Department of Allergy and Clinical Immunology - Namazi Hospital - Shiraz University of Medical Sciences , Alyasin ، Soheila Department of Allergy and Clinical Immunology - Allergy Research Center, Namazi Hospital - Shiraz University of Medical Sciences , Nabavizadeh ، Hesamedin Department of Allergy and Clinical Immunology - Allergy Research Center, Namazi Hospital - Shiraz University of Medical Sciences , Askari ، Aida Department of Allergy and Clinical Immunology - Namazi Hospital - Shiraz University of Medical Sciences
Abstract :
A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses.
Keywords :
Chronic granulomatous disease , Coronavirus disease 2019
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
