Synthesis of 2-amino-4-(4-methoxyphenyl)-1,3-thiazole coatedmagnetic nanoparticles: A potential antibacterial compound

Objective(s): Schiff bases compounds are typically containing a nitrogen analogue of ketone or aldehyde, in which the group of carbonyl is replaced by an azomethine or imine group. These complexes are useful for various industrial goals, catalysis of chemical reactions, and have the capability of using as therapeutic compounds such as anti-microbial, anti-cancer, anti-inflammatory, and antiproliferative. Herein, we report the surface modification of Fe3O4 magnetic nanoparticles by a synthesized Schiff-base, named 2-amino-4-(4-methoxyphenyl)-1,3-thiazole. Methods: Various characterization techniques including, XRD, 13C-NMR, 1H-NMR, SEM, and EDXRF were employed to survey the functional and structural features of the compound. Results: Average particle size for the prepared Fe3O4 magnetic nanoparticles was calculated as about 12nm. SEM confirmed the spherical morphology of magnetic nanoparticles. Moreover, the coated Fe3O4 NPs with Schiff base displayed the desired anti-Escherichia coli and anti-Staphylococcus aureus activity. Conclusions: The herein method is beneficial for the application in diverse fields such as drug delivery, industry, and water treatment.