Author/Authors :
Shademan, Behrouz Department of Medical Biology - Faculty of Medicine - EGE University, Izmir, Turkey , Karamad, Vahidreza Department of Medical Biology - Faculty of Medicine - EGE University, Izmir, Turkey , Nourazarian, Alireza Department of Basic Medical Sciences - Khoy University of Medical Sciences, Khoy, Iran , Biray Avci, Cigir Department of Medical Biology - Faculty of Medicine - EGE University, Izmir, Turkey
Abstract :
Immunotherapy has become a prominent strategy for the treatment of cancer. A method that
improves the immune system’s ability to attack a tumor (Enhances antigen binding). Targeted
killing of malignant cells by adoptive transfer of chimeric antigen receptor (CAR) T cells is a
promising immunotherapy technique in the treatment of cancers. For this purpose, the patient’s
immune cells, with genetic engineering aid, are loaded with chimeric receptors that have
particular antigen binding and activate cytotoxic T lymphocytes. That increases the effectiveness
of immune cells and destroying cancer cells. This review discusses the basic structure and
function of CAR-T cells and how antigenic targets are identified to treat different cancers and
address the disadvantages of this treatment for cancer.
Keywords :
CAR-T cell , Immunotherapy , Surface receptors , Tumor microenvironment
