Title of article
Anti-inflammatory potential of aqueous extract and ethyl acetate fractions of Munronia pinnata (Wall) Theob. and the isolated compound, Senecrassidiol
Author/Authors
Hapuarachchi ، Swarna Damayanthi Unit of Pharmacology and Pharmaceutics, Department of Ayurveda - Institute of Indigenous Medicine - University of Colombo , Suresh ، Thusharie Sugandhika Department of Biochemistry - Faculty of Medical Sciences - University of Sri Jayewardenepura , Hadunnetthi ، Shiroma Institute of Biochemistry, Molecular Biology, and Biotechnology - University of Colombo , Senarath ، Wathuge Thamara Priyanthie Sandun Kumari Department of Botany - Faculty of Applied Sciences - University of Sri Jayewardenepura , Ranasinghe ، Chandani Department of Chemistry - Faculty of Natural Sciences - Open University of Sri Lanka
From page
247
To page
258
Abstract
This study was designed to evaluate in vivo and in vitro anti-inflammatory potential of the different extracts of Munronia pinnata and compare it with the isolated compound, Senecrassidiol by using the carrageenaninduced paw edema animal model in Wistar rats. Munronia pinnata (Wall) Theob (Meliaceae) has been traditionally practiced for hundreds of years by traditional physicians as a home remedy for the treatment of inflammatory conditions in folk medicine in Sri Lanka. The tested ethyl acetate fractions of methanol extract and its isolated compound senecrassidiol exhibited significant antiinflammatory activity in the tested models. It demonstrated the scientific rationale for the use of an antiinflammatory agent in folk medicine. The MPaq showed a significant (p 0.5) inhibition of infiltration of rat peritoneal cells, inhibition of NO production by rat peritoneal cells, and inhibition of membrane stabilization as well as the antihistamine activity which are the probable anti-inflammatory mechanisms.
Keywords
Anti , inflammatory , Folk medicine , Membrane stabilization , Munronia pinnata , Senecrassidiol , Wistar Rats
Journal title
Trends In Phytochemical Research
Journal title
Trends In Phytochemical Research
Record number
2726665
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