Surgical Repair of Nasal Septal Perforation by Mucosal Rotational Flap and Interposition of Cryopreserved Amniotic Membrane

Statement of the Problem: The surgical repair of nasal septal perforation (NSP) has al-ways been a challenging procedure and no consensus has been made about a definitive protocol. Purpose: In the current study, we investigated the use of cryopreserved amniotic mem-brane with mucosal rotational flap for the surgical repair of NSPs. Materials and Method: In this prospective clinical study, 12 patients with symptomatic NSP underwent primary surgical repair, between December 2018 and October 2019. The surgical procedure comprised of a rotational flap on one side of the defect and cryo-preserved amniotic membrane as an interpositional graft in the mucoperichondrial pocket on the other side. The patency of defect was checked at a follow-up appointment at least 3 months after surgery. Results: Successful repair was perceived in 10 of 12 (83%) of patients. Reperforation occurred in two patients but the size of the defect was smaller than the original one. All of the patients reported elimination of all symptoms associated with NSP. Conclusion: The use of cryopreserved amniotic membrane as an interpositional graft accompanied by a mucosal rotational flap seems to be efficient in alleviating the symp-toms of NSP and closure of the defect.