The Association between Adiponectin, Adiponectin Receptor, and Obesity for Diabetic Female Type II

Aims Adiponectin is associated with obesity and unregulated diabetes, although it may be useful considering the consequences of glycemic control and obesity on Adiponectin. This study investigated the association between Adiponectin, Adiponectin Receptor, and Obesity for Diabetic Female Type II. Material & Methods In this research, 54 female patients with type 2 diabetes and 36 non-diabetics participated, individuals from two groups, obese and non-obese, compared with apparently healthy control. The Adiponectin and Adiponectin receptor were measured by ELISA sandwich and Colorimetric methods were used for calculating fasting blood glucose. Blood samples were collected and drawn (5 ml) for each individual. For statistical analysis, SPSS 26.0 by ANOVA and Pearson’s correlation coefficients were used. Findings Adiponectin and the Adiponectin receptor were measured, and the values of both were decreased in patients with type 2 diabetes who have the highest FBG, and also decreased for obese females, which have the highest BMI, where the positive significant values were observed when correlated body mass index (r=-0.57, p=0.001), and fasting blood glucose (r=0.291, p=0.0.06), while a negative correlated observed between Adiponectin receptor (r=-0.59, p=0.203) and Adiponectin (r=-0.201, p=0.158). Conclusion The adipo levels, which consider a pro-inflammatory marker for obesity enhance complications such as metabolic syndrome, insulin resistance, ischemic heart disease, and diabetic renal disease for women obese diabetes patients compared with non-obese diabetes patients.