Studying the Role of Interleukin-6, C-Reactive Protein, and Nitric Oxide Synthase in Obese, Diabetic, and Sub-Fertile Men

Aims This study aimed to investigate the role of Interleukin-6, C-reactive protein, and Nitric oxide synthase in obese, diabetic, and sub-fertile men. Material & Methods The current study was conducted in some health centers in Misan province, Iraq, from December 2020 to July 2021. The whole sample included 80 men aged 35-45 years, divided into four groups (20 men/group). Eight to ten milliliters of venous blood samples were drawn at 9 - 11 am, using a disposable needle and plastic syringes for each man. The blood was left at room temperature for 15 minutes for coagulation, centrifuged at 300orpm for 5 minutes, then serum and plasma were separated and transferred for storage. Statistical analysis was performed by IBM SPSS 23 using ANOVA. Findings Results revealed: Interleukin-6 increased significantly (p<0.05), except in the diabetic group, in different groups in comparison with the control, C-reactive protein increased significantly (p<0.05) in different groups in comparison with the control, Nitric oxide synthase decreased significantly (p<0.05), except in sub-fertility group, in different groups in comparison with the control. Conclusion The Interleukin-6 and C-reactive protein increment and Nitric oxide synthase reduction in different groups might be indicated a pro-inflammatory action and low fertility in obesity, diabetic and sub-fertility groups.