Title of article :
Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
Author/Authors :
Zoofaghari, Shafeajafar Department of Clinical Toxicology - Isfahan Clinical Toxicology Research Center - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Wong, Anselm Emergency Department - Austin Toxicology Unit, Victorian Poisons Information Centre, Austin Health, Victoria, Australia , Kiarasi, Pegah Department of Clinical Toxicology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Gheshlaghi, Farzad Department of Clinical Toxicology - Isfahan Clinical Toxicology Research Center - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of
many types of mental disorders. Citalopram is commonly used as a new generation
of SSRIs in this regard; however, unfortunately, its overdose is associated with
seizure and heart disorders. The reported case in the present study indicated
recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to
the overuse of citalopram. The patient had bilateral anterior shoulder dislocation
along with right proximal humerus fracture that was occurred during the seizure.
The dislocation was initially reduced and then fixed. Moreover, the seizure was
controlled with diazepam without any problems, and cardiac monitoring continued
for 2 days. Massive citalopram overdose may be associated with recurrent seizures
and QT prolongation. Complications postseizures, such as shoulder dislocations,
should be examined for and managed appropriately.
Keywords :
Citalopram , shoulder dislocation , seizure , Citalopram
Journal title :
Journal of Research in Pharmacy Practice
