A Traditional Iranian Medicine (Majoon-e Loboob) for Idiopathic Male Infertility: A Case Series

Infertility is defined as the inability to conceive after 12 or more months of regular intercourse without contraception. Sperm abnormalities are introduced as 20-47% of infertility etiology. Idiopathic male subfertility is common (40-50%). In the Iranian traditional medicine, many natural drugs are used for enhancing fertility. This case series was an effort to understand the role of an Iranian traditional formulation in conception. For this purpose, 13 men with infertility and idiopathic oligoasthenoteratospermia were treated by 10 g Majoon-e Loboob twice daily. 11 (84.6%) of their wives became pregnant after 4.8 ± 2.0 months. In men with severe oligoasthenospermia (< 0.1 × 106/ml), no pregnancy occurred and their spermogram remained unchanged. However, libido and erectile function showed improvement in all patients. No adverse events have been reported by patients. Majoon-e Loboob could be considered as a complementary medicine for treatment of idiopathic infertility. Some of the natural components in this formulation have proven pharmacological activity in conception including Zingiber officinale and Myristica fragrans.