Author/Authors :
Ansari Djafari, Anahita Laser Application in Medical Sciences Research Center - Shohada-e-Tajrish Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rahavian, Amirhossein Andrology Research Center - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Javanmard, Babak Urology Department - Shohada-e-Tajrish Hospital - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Montazeri, Saeed Urology Department - Shohada-e-Tajrish Hospital - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Shahabi, Vahid Urology Department - Shohada-e-Tajrish Hospital - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hojjati, Ali Urology Department - Shohada-e-Tajrish Hospital - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghiasy, Saleh Urology Department - Shohada-e-Tajrish Hospital - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hamidi, Ramin School of Medicine - 501 Hospital (Imam Reza) - AJA University of Medical Science, Tehran, Iran , Khoshnevis, Jalaluddin Clinical Research Development Unit - Shohada-e-Tajrish Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Fournier’s gangrene (FG) is a life-threatening disease, even with early diagnosis and administration
of vigorous treatment, its mortality rate is high. This study aimed to evaluate the factors relate to mortality
in patients with FG or necrotising fasciitis managed in a referral center. Methods: This retrospective crosssectional
study was conducted on patients managed in a tertiary referral center, Tehran, Iran, from March 2009
toMarch 2019, with diagnosis of FG or necrotising fasciitis. The correlation between different demographic and
clinical parameters with mortality was analysed and reported. Results: 73 cases with the mean age of 59.1 ± 15.8
(range: 25 – 88) years were studied (87.7% male). 21 (28.8%) patients died. Escherichia coli (26 cases, 35.6%)
was the most frequent microorganism in cultures. Non-survived cases had higher mean age (p = 0.01), higher
frequency of hyperlipidaemia (p = 0.02), immunosuppression (p < 0.001), longer hospital stay (p=0.02), lower
blood pressure (p=0.01), and lower platelet count (p=<0.001). Based on multivariate analysis, age (p = 0.015;
Odds: 0.88 (0.79-0.97)), haematocrit level (p = 0.01; Odds: 1.27 (1.04-1.55)), platelet count (p = 0.03; Odds: 10.11
(1.14-89.35)), and immunosuppression (p = 0.01; Odds: 0.01 (0.0-0.54))were independent related factors of mortality.
Conclusion: The rate of mortality due to FG and necrotizing fasciitis was 28.8%. Based on multivariate
analysis, the independent related factors of mortality were older age, lower haematocrit level and platelet count,
and presence of immunosuppression.
Keywords :
Fournier’s Gangrene , Fournier’s Gangrene Severity Index , Mortality , Thrombocytopenia
