Author/Authors :
Rezaei-Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rostami Nejad, Mohammad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Arjmand, Babak Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Rezaei Tavirani, Sina Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Razzaghi, Mohammadreza Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mansouri, Vahid Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients’
plasma proteins have revealed new information about the disease. Introducing the key targeted plasma
protein in fatal conditions of COVID-19 infection is the aim of this study. Methods: Significant differentially
expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an
original article. These proteins were included in a network via STRING database along with 100 first neighbor
proteins to determine central nodes of the network for analyzing. Results: Queried and added proteins were
included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried
hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and
Fibrinogen beta chain (FGB), which are related to the coagulation process. Conclusion: It seems that fibrinogen
dysregulation has a deep impact on the fatality of COVID-19 infection.
Keywords :
SARS-CoV-2 , Proteomics , Proteins , Protein Interaction Maps , Fibrinogen
