Author/Authors :
Ihsan Rashan, A Department of Pharmacy - Al-Hadba University College, Mosul, Iraq , Mahdi Rheima, A College of technical engineering - The Islamic University, Najaf, Iraq - Department of Optics Techniques - Dijlah University College - Al-Masafi Street - Al-Dora, Baghdad, Iraq , Ghadhanfar Alwan, M Medical laboratory techniques Department - Medical (Technology) College - Al-Farahidi University, Baghdad, Iraq , Abed Jawad, M Al-Nisour University College, Baghdad, Iraq , Mohammed, H. T Anesthesia Techniques Department - Al-Mustaqbal University College, Babylon, Iraq , Gaber Abdel Razzaq, M Al-Manara College For Medical Sciences, Misan, Iraq , Ahmed Al-Taweel, A Al-Esraa University College, Baghdad, Iraq , Attia Thijail, H College of Health and Medical Technology - Al-Ayen University, Thi-Qar, Iraq , Ahjel, S Department of Pharmacy - Al-Zahrawi University College, Karbala, Iraq , Jalil Obaid, A Medical Laboratory Techniques Department - Hilla University College, Babylon, Iraq
Abstract :
Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that
grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was
designed to investigate serum values of IL-23 in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. A total of 372 individuals were divided into 2 groups (n=186) as follows: Group A comprising 186 infected participants with brucella (7-80 years-old), these people had not received antibiotics for at least 6 months ago. Group B including the healthy participants. All the participants in both groups were in the same age range. 5 ml blood samples were obtained from the participants
intravenously (without anticoagulation substance). The serum level of IL-23 was investigated by ELISA
diagnostic kit. The recorded data showed that the levels of IL-23 in the serum samples obtained from group A
(143.64 Pg/ml) significantly (P<0.001) increased compared with this value in group B (23.14 Pg/ml). Based on
the recorded data in the forms completed by all the participants at the day 0 of the experiment, 44 out of 186
individuals in group A, had experienced Brucellosis attack 2-3 times in spite of receiving medical prescriptions.
A hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. Results illustrated failure to respond to conventional medical therapy in patients with low level of serum IL-23.
Keywords :
IL-23 , Serum value , Brucellosis , Medical therapy
