Author/Authors :
Alipoor, Elham Department of Nutrition - School of Public Health - Iran University of Medical Sciences, Tehran, Iran , Hosseinzadeh-Attar, Mohammad Javad Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Salehi, Shiva Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Dahmardehei, Mostafa Department of Plastic Surgery - Burn Research Center - Motahari Hospital - Iran University of Medical Sciences, Tehran, Iran , Yaseri, Mehdi Department of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Emami, Mohammad Reza Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Hajian, Mehdi Motahari Hospital - Iran University of Medical Sciences, Tehran, Iran , Rezayat, Mahdi Department of Pharmacology - School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Jazayeri, Shima Department of Nutrition - School of Public Health - Iran University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Collagen and omega-3 fatty acids (FAs) are suggested to have anti-inflammatory, anti-oxidant,
and insulin-sensitizing properties. The aim of this study was to investigate the effect of collagen hydrolysate and
omega-3 FAs on inflammation and insulin resistance in patients with major burns. Methods: In this doubleblind
randomized clinical trial, 66 patients with 20-45% burns were assigned to either of the three groups of
collagen (40 gr/d), collagen (40 gr/d) plus fish oil (10 ml/d), or control. High-sensitivity C-reactive protein (hs-
CRP), fasting blood glucose (FBG) and insulin concentrations, and homeostatic model assessment for insulin
resistance (HOMA-IR) were assessed at baseline, as well as end of weeks two and three. Results: Based on posthoc
analyses, hs-CRP levels were significantly lower in the collagen (p=0.026) and collagen+omega-3 (p=0.044)
groups compared to the control group, at week three. However, pre- to post- (week three) changes of hs-CRP
were significantly higher only in the collagen+omega-3 group compared to the control group (173.2 vs. 103.7
mg/l, p=0.024). After three weeks of the intervention, insulin (11.3 and 11.9 vs. 22.8 &IU/ml) and HOMA-IR (2.9
and 2.8 vs. 7.9) values seemed to be clinically, but not statistically, lower in both intervention groups compared
to the control group. Pre- to post- (week three) values of FBG decreased significantly in the collagen (p=0.002)
and collagen+omega-3 (p=0.036) groups. Insulin (p=0.008) andHOMA-IR (p=0.001) decreased significantly only
in the collagen+omega-3 group at week three compared to the baseline. Conclusion: Supplementation with
collagen hydrolysate and omega-3 FAs can improve hs-CRP concentration and probably insulin resistance in
patients with severe burns. Omega-3 FAs had additional effects on modulating inflammation. Larger clinical
trials are needed to confirmthe current findings especially in terms of glucose homeostasis.
Keywords :
Burns , Collagen , Inflammation , Insulin resistance , Fatty Acids , Omega-3
