Author/Authors :
SeyedAlinaghi, Ahmad Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Mohsseni Pour, Mehrzad Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Saeidi, Solmaz Department of Nursing - Khalkhal University of Medical Sciences, Khalkhal, Iran , Habibi, Pedram Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Dashti, Mohsen Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Nazarian, Newsha School of Medicine - Islamic Azad University, Tehran, Iran , Noori, Tayebeh Department of Health Information Technology - Zabol University of Medical Sciences, Zabol, Iran , Pashaei, Zahra Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Bagheri, AmirBehzad Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Ghasemzadeh, Afsaneh Department of Radiology - Tabriz University of Medical Sciences, Tabriz, Iran , Afsahi, Amir Masoud Department of Radiology - School of Medicine - University of California, California, USA , Aghaie, Narjes School of Nursing and Midwifery - Tehran University of Medical Sciences, Tehran, Iran , Mojdeganlou, Paniz Shahid Beheshti University of Medical Sciences, Tehran, Iran , Arjmand, Ghazal Shahid Beheshti University of Medical Sciences, Tehran, Iran , Zargari, Ghazal School of Medicine - Iran University of Medical Sciences, Tehran, Iran , Modiri, Roshanak Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran , Mojdeganlou, Hengameh Department of Pathology - Urmia University of Medical Sciences, Urmia, Iran , Razi, Armin School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Mehraeen, Esmaeil School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Dadras, Omid Iranian Research Center for HIV/AIDS - Iranian Institute for Reduction of High Risk Behaviors - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Rare serious complications have been documented after COVID-19 vaccination as clinical research
proceeded and new target populations, such as children and pregnant women, were included. In
this study, we attempted to review the literature relevant to pregnancy complications and maternal outcomes
of COVID-19 immunization in pregnant women. Methods: We searched the databases of PubMed, Scopus,
Cochrane, and Web of Science on 31 August 2022. The records were downloaded and underwent a two-step
screening; 1) title/abstract and then 2) full-text screening to identify the eligible studies. We included English
original studies that evaluated the adverse effects of COVID-19 vaccines during pregnancy. Information such
as the type of study, geographical location, type of vaccine injected, gestational age, maternal underlying diseases,
and complications following the vaccination were extracted into pre-designed tables. Results: According
to the findings of included studies, in most of them vaccination had a positive impact and no negative effects
were observed. Also, no medical history was reported in 11 articles, and pregnant women had no underlying
diseases. Some serious adverse events were reported after vaccination, including miscarriage, paresthesia, uterine
contraction, vaginal bleeding, preterm birth, major congenital anomalies, intrauterine growth restriction,
and seizure. Conclusion: Because of limited data availability and the cross-sectional design of most studies,
we could neither infer causation between vaccines and incidence of adverse effects nor comment with certainty
about any possible adverse outcome of COVID-19 vaccines in vaccinated pregnant women. Consequently, more
longitudinal and experimental studies are needed to define the exact adverse effects of COVID-19 vaccines in
pregnant women.
