Title of article :
Ubiquinone [Q10] and Dentate Gyrus Ischaemia Reperfusion Injury in a Rat Model of Brain Ischaemia
Author/Authors :
Talebi Tadi ، Niloofar Department of Anatomical Sciences and Cognitive Neuroscience - Faculty of Medicine - Islamic Azad University, Tehran Medical Sciences , Movasseghi ، Shabnam Department of Anatomical Sciences and Cognitive Neuroscience - Faculty of Medicine, Herbal Pharmacology Research Center - Islamic Azad University, Tehran Medical Sciences , Nazarnejad ، Mohammad Mahdi Department of Anatomical Sciences and Cognitive Neuroscience - Faculty of Medicine - Islamic Azad University, Tehran Medical Sciences , Sharifi ، Zahra Nadia Department of Anatomical Sciences and Cognitive Neuroscience - Faculty of Medicine, Herbal Pharmacology Research Center - Islamic Azad University, Tehran Medical Sciences
Abstract :
Introduction: This research was conducted to evaluate the effect of ubiquinone following ischemia/reperfusion on dentate gyrus in Wistar rats. Materials and Methods: Twenty-four Rats were randomly assigned to four groups [n=6] . Common carotid arteries were bilaterally closed for 20 minutes in order to perform ischemic model. Four days later, all rats were slaughtered and hippocampal tissue was examined by Nissl staining method. Results: The data showed that ubiquinone had a neurotrophic effect on dentate gyrus cells of hippocampal region in ischemia/reperfusion model. Conclusion: Our findings adduce the argument that ubiquinone can be used to treat brain lesions following ischemia.
Keywords :
Dentate gyrus , Ubiquinone , Wistar rat
Journal title :
Archives of Advances in Biosciences
Journal title :
Archives of Advances in Biosciences
