Simultaneous Electrochemical Analysis of Ibuprofen and Paracetamol by Clay Modified Carbon Paste Electrode: Analytical Application in Human Blood

Cyclic voltammetry and differential pulse voltammetry techniques for the simultaneous analysis of ibuprofen (IBU) and paracetamol (PCT) at carbon paste electrode modified with clay (CPE-Clay) are reported. The surface characterization of the clay was realized by zero-point charge and electrochemical methods. The electrocatalytic activity of clay toward ibuprofen electro-oxidation and paracetamol redox were reported. The kinetic parameters for ibuprofen and paracetamol electro-analysis by the modified carbon paste electrode clay-CPE were calculated. Peak ibuprofen oxidation and peaks paracetamol redox were well presented onto modified electrode clay-CPE when compared with other electrodes in the literature. Peak oxidation of the ibuprofen and peaks paracetamol redox was well presented onto modified electrode clay-CPE compared with other electrodes in the literature. The high sensitivity of the clay-CPE is measured by the DPV method showed linear variation with ibuprofen and paracetamol concentration with respectively detection limit (LOD) of 3.23×10-8 mol L-1 and 1.04×10-8 mol L-1. The applicability of the working electrode has been explored by the simultaneous electroanalysis of the ibuprofen and paracetamol in human blood samples.