Author/Authors :
Zargaran, Arman Department of Traditional Pharmacy - School of Traditional Medicine - Tehran University of Medical Sciences - Tehran , Faridi, Pouya Pharmaceutical Sciences Research Center - Department of Phytopharmaceuticals (Traditional Pharmacy) - School of Pharmacy and Research Office for the History of Persian Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Daneshamouz, Saeid Department of Pharmaceutics - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz, Iran , Borhani-Haghighi, Afshin Clinical Neurology Research Center and Department of Neurology - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Azadi, Amir Pharmaceutical Sciences Research Center - Department of Phytopharmaceuticals (Traditional Pharmacy) - School of Pharmacy and Research Office for the History of Persian Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Hashempur, Mohammad Hashem Department of Traditional Medicine - Fasa University of Medical Sciences, Fasa, Iran , Mohagheghzadeh, Abdolali Department of Phytopharmaceuticals (Traditional Pharmacy) - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Medicinal oils were of the pharmaceutical dosage forms used since ancient Persian times to now in
Iran. Chamomile oil is one of the medicinal oils prepared by the extraction of the chamomile
flowers to sesame oil as an oily vehicle. It was widely used in the history of Persian medicine and
is currently used by traditional practitioners of Persian Medicine in various disorders mainly in
topical form. In this study, traditional chamomile oil was prepared based on the Qarabadin books.
In advanced, 600 g of chamomile flower powder was boiled in 3.6 liter of water for 3 hours. Then,
powder was removed and remained water (aqueous extract of chamomile) was boiled with 0.5 liter
of sesame oil for 2 hours (until all the water was vaporized and oil remained). For standardization,
the essential oil of chamomile oil was obtained via Clevenger apparatus method and then analyzed
with the help of gas chromatography (GC)-mass method. In addition, total phenolic and flavonoid
contents of the chamomile oil were calculated based on galic acid and quercetin, respectively. The
results show that the main component of the essential oil were Caryophyllene (7.45%), Bisabolol
Oxide B (2.05%), Bisabolone Oxide A (62.35%), Chamazulene (2.05%), Bisabolol Oxide A
(15.54%) and Methyl ester 5,8,11-Heptadecatriynoic acid (5.52%). Besides, total phenolic and
flavonoid contents were 11.0043 ± 0.4514 and 2.7640 ± 0.1776 mg/l, respectively. Our results
show that the historical dosage form of chamomile oil in Persian medicine can be reproduced and
is an stable and homogeneous oil and be standardized in our investigation.
Keywords :
Persian Medicine , Chamomile oil , Pharmaceutic , Traditional medicine
