Cytotoxicity Effect of Arnebia Euchroma against Human Gastric Adenocarcinoma Cell Line (AGS)

most common cause of death from cancer in Iran and now despite all the progress made, the 5-year survival of patients is generally 15%. Thus, improvement in current treatments seems necessary. Given the richness of Iranian medicine in ancient texts, a detailed study of the effects of medicinal plants native to Iran in particular is essential. In this research, the cytotoxicity effect of Arnebia euchoromaon AGS was reviewed. Materials and Methods: In this study, cells were cultured in RPMI at different concentrations of Arnebia euchoroma extract (5,2,1,0.2,0.1,0.05 and 0.02 mg/ml) at intervals of 24,48 and 72 h and the number of living cells compared with the control group and cytotoxicity effect were measured by MTT assay. Results:Within 24 hours, drug effects on reduction of cell growth of AGS in comparison to the control group at 5, 1, 0.1, 0.05 and 0.02 mg/ml were significant (P values are 0.0305, 0.0465, 0.0137, 0.0274 and 0.0003, respectively). Within 48 hours, concentrations of 0.1 and 0.02 mg/ml were significant (P values are 0.0398 and 0.0143).Within 72 hours, 5, 0.05 and 0.02 mg/ml reductions were significant (P values are 0.0402, 0.0073 and 0.0349, respectively). Conclusion: According to the results, Arnebia euchoroma significantly has no killing effect on AGS. Only in the 0.02 mg/ml concentrations the reduction was significant at three times, with a fatality rate of about 20%, which is not enough to be considered cytotoxic.