Electrochemical Investigation for Sensitive Determination of Metoclopramide Based on Ytterbium Oxide Nanoparticles Supported on Graphene

A novel glassy carbon electrode (GCE) modified with 1-(E)-4-((2-(2,4-dinitrophenyl)hydrazono)methyl)benzene-1,2-diol (DDH) and reduced graphene oxide-ytterbium nanoparticles (rGO-Yb2O3 NP) for the determination of metoclopramide (MC) was successfully fabricated. The electrochemical behavior of the modified electrode (rGO-Yb2O3-DDH/GCE) was investigated by common and practical methods including differential pulse voltammetry, chronoamperometry and cyclic voltammetry. It was found that the rGO-Yb2O3-DDH composite has a coherent electrocatalytic role in the oxidation of metoclopramide with relatively high stability, lifetime and sensitivity. The characterization of the nanocomposite was done by X-ray diffraction, Fourier transform infrared spectroscopy and field emission scanning electron microscopy. The MC oxidation took place at the optimum pH of 7.0 and a potential that was about 810 mV more negative than that at unmodified GCE. Under optimized conditions, the corresponding linear calibration curves were found to be in the linear dynamic range of 25.0-3000.0 μM with the detection limit of 7.14 μM. Finally, the proposed electrode was successfully used to measure MC in blood serum samples.