Cytotoxic activity and Magnetic Behavior of green synthesized iron oxide nanoparticles on brain glioblastoma cells

Iron oxide nanoparticles are one of the most applied metal nanoparticles with advantageous properties in biomedicine that can be cost-effectively and rapidly produced through green synthesizing methods. The purpose of this study was to study the toxicity of iron oxide nanoparticles (Fe2O3 NPs), which were green synthesized by Prosopis farcta extract, on brain glioblastoma cells (U87). Powder X-ray Diffraction (PXRD), Vibrating-Sample Magnetometer (VSM), Field Energy Scanning Electron Microscopy (FESEM), Energy-Dispersive Spectroscopy (EDX), and Raman technics were performed to evaluate the physicochemical properties of this product. According to results, the green synthesized Fe2O3 nanoparticles contained a spherical morphology in the size range of 20-45 nm with superparamagnetic features. Additionally, their cytotoxic activity was surveyed against U87 cells by MTT assay, and the outcomes indicated the lack of any cytotoxic activity until reaching the concentration of 500 μg/mL. Therefore, our synthesized Fe2O3 NPs can be proposed as a proper candidate for being applied in the drug delivery of cancer treatments.