Author/Authors :
Amirmoeini, Mehrdad Department of Immunology and Allergy - Mofid’s Children Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Chavoshzadeh, Zahra Department of Immunology and Allergy - Mofid’s Children Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rahimi, Arezou Department of Immunology - Faculty of Medical Sciences - Tarbiat Modarres University, Tehran, Iran , Nabavi, Mohammad Department of Allergy and Clinical Immunology - Rasoul Akram Hospital - Iran University of Medical Sciences, Tehran, Iran , Mahdaviani, Alireza Pediatric Respiratory Diseases Research Center- N, ational Research Institute of Tuberculosis and Lung Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Darougar, Sepideh Department of Pediatrics - Tehran Medical Sciences Branch Islamic Azad University, Tehran, Iran , Armin, Shahnaz Pediatric Infections Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Darougar, Sepideh Department of Pediatrics - Tehran Medical Sciences Branch Islamic Azad University, Tehran, Iran , Mesdaghi, Mehrnaz Department of Immunology and Allergy - Mofid’s Children Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background: IL-17 producing T cells are a distinct subset of CD4+ T cells, which are recognized to have an essential role in protection against certain fungi and extracellular pathogens.
Objectives: This study aims to evaluate the number of IL-17 producing T cells as a predictor of primary immunodeficiency disorders in patients with Candida infections and low numbers of IL-17 producing T cells.
Methods: Seven newly diagnosed patients with documented Candida infections aged between 4 and 35 years were included in this study. Before establishing the diagnosis of chronic mucocutaneous candidiasis, a thorough immunodeficiency workup, includ-ing complete blood count, serum Ig levels and antibody responses, flow-cytometry evaluation, and LTT, was completed for all the patients, and other immunodeficiency disorders, including combined and phagocytic deficiencies, were ruled out. Then, IL-17 pro-ducing T cells were detected using antiCD3 and anti-IL-17 antibodies through flow-cytometry evaluation.Results: The IL-17 producing T cells significantly decreased in the peripheral blood of patients with PID and candida infections. A
Keywords :
Candida , Primary Immunodeficiency , T Cells , L-17 Producing
