Author/Authors :
Maleki, Mohsen Department of Nutrition - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran , Karajibani, Mansour Health Promotion Research Center - Department of Nutrition - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran , Sarvani, Mohsen Cellular and Molecular Research Center - Research Institue of Cellular and Molecular Sciences in Infectious Diseases - Zahedan University of Medical Sciences, Zahedan, Iran , Montazerifar, Farzaneh Pregnancy Health Research Center - Department of Nutrition - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran , Salimi, Saeedeh Cellular and Molecular Research Center - Research Institue of Cellular and Molecular Sciences in Infectious Diseases - Zahedan University of Medical Sciences, Zahedan, Iran , Heidari, Zahra Department of Endocrinology and Metabolism - Zahedan University of Medical Sciences, Zahedan, Iran
Abstract :
About 60-80% of thyroid cancer (TC) cases are papillary thyroid cancer (PTC). Studies
have shown that serum adiponectin levels are inversely related to the risk of TC and PTC. Aim
of the present study was to evaluate the association between adiponectin rs2241766 and
rs266729 polymorphisms and risk of PTC. 122 PTC patients and 128 healthy subjects were
enrolled in the study. PCR-RFLP and ARMS-PCR methods were used for genotype analysis.
The rs266729 polymorphism did not correlate with risk of PTC. As regard rs2241766
polymorphism, the frequency of the GG genotype did not have a significant difference between
the two groups, although, PTC cases showed higher frequency of GT genotype compared to
controls (OR=2.87, 95% CI=1.56-5.28, P=0.001). We observed a significant association
between adiponectin rs2241766 polymorphism and PTC, however, our result showed no
significant relationship between adiponectin rs266729 polymorphism and risk of PTC.
