Role of calcium/potassium coefficient in calcium-regulating hormone activity in pre-obese patients

Obesity is a heterogeneous group of conditions and syndromes caused by hormonal metabolic disorders and many other factors. The aim of the work is to establish Ca/K coefficients role to gain weight. An assessment of changes in the characteristics of mineral, biochemical, and hormonal metabolism was carried out in 100 practically healthy patients of both sexes living in Grodno, Belarus. The age of the examined patients was 24.3±0.24 for females and 25.5±0.52 for males. The results show a clear, significant, and correlation-dependent imbalance in the elemental status in overweight patients, both men and women, in the age group of patients ≥ 18 years, which has an imbalance in hormonal levels (pituitary hormones-TSH, thyroid hormones-T3/T4 free, and adrenal hormones cortisol), metabolites, substrates, and enzymes of blood plasma (glucose, cholesterin, LDL cholesterol, triglycerides, and alanine aminotransferase). The imbalance established in blood serum samples for bioelements (Ca and K), for which there are similar changes in hair samples, suggests that these disorders are associated with metabolic processes in the body, which are expressed in an increase in body weight. The hair Ca/K ratio was greater than 5 in 64% of males with a BMI of 25–29.9. As a result, it is clear that increasing body weight causes a 64% elevation in the activity of hormones regulating calcium, which was not previously considered in the literature. In 92% of females, the increased body weight maximized the activity of calcium-regulating hormones.