Synergistic effects of curcumin with other herbal compounds and chemical polymers in the preparation of wound dressings: A systematic review

Curcumin is among the herbal substances that are of high significance for many researchers as a wound dressing and a wound-healing substance. Curcumin s functioning can be substantially improved by its blending with other natural and industrial components. A systematic review was conducted by searching queries in reliable databases, including Scopus, Web of Sciences, and PubMed. The search results were screened by two researchers employing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) algorithm. A total of 320 studies were identified, of which 11 were chosen for evidence synthesis. According to the studies, the antimicrobial effect (in 8 studies), mechanical properties (in 7 studies), electrospinning (in 8 studies), and cytotoxicity (in 6 studies) in wound dressings were parameters significantly influenced by blending curcumin with other herbal components and chemical polymers. According to the evidence synthesis results, herbal compounds combined with curcumin improve and strengthen the wound healing property of curcumin.