Title of article :
Ionic Channel Blockage Effect on the Electromechanical Model of Human Gastric Wall Smooth Muscle Cells
Author/Authors :
Taghadosi ، H. Department of Biomedical Engineering - Islamic Azad University, Tehran Science and Research Branch , Tabatabai Ghomsheh ، F. Pediatric Neurorehabilitation Research Center - University of Social Welfare and Rehabilitation Sciences , Jafarnia Dabanloo ، N. Department of Biomedical Engineering - Islamic Azad University, Tehran Science and Research Branch , Farajidavar ، A. Department of Electrical and Computer Engineering - New York Institute of Technology
Abstract :
In this paper, a three-dimensional electromechanical model is presented to investigate the effect of calcium and potassium ionic channels on the contractile behavior of human gastric wall smooth muscle cells with the finite element approach. In this model, simultaneous electrical and mechanical interactions of 240-cells and 548-links were considered. Electrophysiological interactions of cells through ion channels with the extrascellular environment and gap junctions with adjacent cells lead to the production and propagation of slow waves in smooth muscle. This wave causes contraction and peristaltic movements in the muscles of the gastric wall. By blocking calcium and potassium ionic channels by pharmacological agents can be improved disorders caused by these movements and contractions and brought them closer to the physiological state.
Keywords :
Electromechanical model , Smooth muscle cell , Gastric , Ion Channel Blocker , Contraction
Journal title :
Iranian Journal of Mechanical Engineering Transactions of the ISME
Journal title :
Iranian Journal of Mechanical Engineering Transactions of the ISME
