Title of article :
Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds
Author/Authors :
Muslim ، Rasim Farraj Department of Environmental Sciences - College of Applied Sciences-Hit - University of Anbar , Majeed ، Ismaeel Yaseen Department of chemistry - College of education for pure science-Ibn Al-Haitham - University of Baghdad , Saleh ، Suheb Eaid Directorate of Education in Anbar - Ministry of Education , Saleh ، Marwan Mahmood Department of Biophysics - College of Applied Sciences-Hit - University of Anbar , Owaid ، Mustafa Nadhim Department of Heet Education - Directorate of Education in Anbar - Ministry of Education , Abbas ، Jalal Abdulkareem Department of Chemistry - Faculty of Science - Gazi University
Abstract :
In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff s bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3 -(pyrimidin-2-yl) spiro[indoline-3,2 -oxazolidine]-2,5 -dione (J4), inhibited the development of both gram-negative and positive bacteria.
Keywords :
Heterocyclic , Oxazolidine , 5 , one , Biological activity , MICs
Journal title :
Journal of Chemical Health Risks
Journal title :
Journal of Chemical Health Risks
