Title of article :
Age-Specific Reference Intervals for Routine Laboratory Biochemical Tests in The Iranian Adolescent Girls
Author/Authors :
Pashirzad ، Mehran Department of Clinical Biochemistry - Faculty of Medicine - Mashhad University of Medical Sciences , Ghazizadeh ، Hamideh International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Student Research Committee - Mashhad University of Medical Sciences , Seddigh Shamsi ، Mohsen Department of Internal Medicine - School of Medicine - Mashhad University of Medical Sciences , Yaghooti-Khorasani ، Mahdiyeh International UNESCO Center for Health-Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences , Assaran Darban ، Reza Department of Biology - Faculty of Sciences - Islamic Azad University, Mashhad Branch , Kamel Khodabandeh ، Atieh Social Determinants of Health Research Center - Mashhad University of Medical sciences , Akbarpour ، Ensieh Social Determinants of Health Research Center - Mashhad University of Medical sciences , Mohammadi Bajgiran ، Maryam International UNESCO Center for Health-Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences , Mansouri ، Amin International UNESCO Center for Health-Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences , Javid Dash Bayyaz ، Reza Student Research Committee - Mashhad University of Medical Sciences , Asadian ، Parisa Department of Biology - Faculty of Sciences - Islamic Azad University, Mashhad Branch , Khanizadeh ، Khashayar Department of Nutrition Sciences - Varastegan Institute for Medical Sciences , Akhtari ، Hale Department of Nutrition Sciences - Varastegan Institute for Medical Sciences , Hadizadeh ، Melika Department of Nutrition Sciences - Varastegan Institute for Medical Sciences , Babaei ، Arvin Department of Nutrition Sciences - Varastegan Institute for Medical Sciences , Khayatzadeh ، Saeid International UNESCO Center for Health-Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences , Ferns ، Gordon A. Division of Medical Education - Brighton Sussex Medical School , Esmaily ، Habibollah Social Determinants of Health Research Center - Mashhad University of Medical sciences , Ghayour-Mobarhan ، Majid InInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Metabolic Syndrome Research Center - Mashhad University of Medical Sciences
Abstract :
Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geographical region, measurement device, and type of kits and reagents for routine laboratory biochemical variables in healthy adolescent girls aged 12-19 years. Materials and Methods: In this cross-sectional study a total of 1026 adolescent girl was recruited. According to the study aim, the levels of serum for some routine biochemical tests were measured on a BT-3000 auto-analyzer. On the basis of the non-parametric rank method and by use of CLSI Ep28-A3 guidelines, we determined age-specific RIs, including confidence interval 90%, under specific exclusion criteria. Results: Age partitioning was required for none of the upper and lower limits of biochemical markers. All Serum biochemical tests concentration remained relatively constant throughout the age range. Conclusion: By removing and/or limiting critical gaps involved in reference values of biochemical tests, it has provided an important understanding of metabolic processes and it has facilitated clinical application to track different diseases better.
Keywords :
adolescent girls , Biochemical markers , CLSI guidelines , Reference intervals
Journal title :
Journal of Cardio- Thoracic Medicine
Journal title :
Journal of Cardio- Thoracic Medicine
