Title of article :
Synthesis and characterization of new 4,6-dimethoxy-1H-indole derivatives as antibacterial and antitumor agents
Author/Authors :
Mubarak ، Hayfaa A. Chemical Engineering Department - College of Engineering - University of Babylon , Hussein ، Alaa Ali Department of Chemistry - College of Education for Girls - University of Mosul , Jawad ، Wisam Abdul Jaleel Department of Chemistry - College of Science - University of Babylon , Karhib ، Mustafa M. Department of Medical Laboratory Techniques - Al-Mustaqbal University College , Abd Alrazzak ، Nour Department of Chemistry - College of Science for Women - University of Babylon , Kareem ، Mohanad Mousa Department of Chemistry - College of Science - University of Babylon , Naje ، Ahmed Samir College of Engineering - AlQasim Green University
Abstract :
New heterocyclic compounds derived from 4,6-Dimethoxy-1H-indole were synthesized. 4,6-Dimethoxy-1H-indole was reacted with chloroacetic acid to produce compound (R1) which used as starting material to synthesized pyrazole, isoxazole, and pyrimidine derivatives respectively. Compound (R1) reacted with urea and thiourea to produce diazetidin-2-one (R2) and diazetidine-2-thione (R3). On the other hand, (R1) was combined with thiosemecabazide to produce thiadiazole (R4) which combined with benzaldehyde in acetic acid to yield Schiff base compound (R5). This compound used as starting material to creation compounds (R6-R11) via reaction with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, acetamide, urea, and thiourea respectively. Anticancer and antibacterial activity of the synthesized compounds was investigated with good results. Compounds R3, R6, R9 and R11 with (NH) group demonstrated strong activity against MCF7 cells, the IC50 values range between 31.06 - 51.23 µg/mL.
Keywords :
anticancer activity , diazetidine , Isoxazole , triazolidine , Pyrazoline
Journal title :
Eurasian Chemical Communications
Journal title :
Eurasian Chemical Communications
