Title of article
Influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome
Author/Authors
Banihashemi ، Mojgan Departement of Physical Education and Sport Sciences - Faculty of Education and Psychology - University of Mohagheghe Ardabili , Yazdkhasti ، Ensiyeh Departement of Physical Education and Sport Sciences - Faculty of Education and Psychology - University of Mohagheghe Ardabili , Mahmoudi Haghshenas ، Maryam Department of Sport Physiology - Faculty of Physical Education - Islamic Azad University , Rostamkhani ، Fatemeh Department of Biology - Islamic Azad University, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch
From page
47
To page
53
Abstract
The aim of this study was to investigate the influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome. In this experimental study, 32 male Wistar rats (120 to 130 g) were selected and after 12 weeks of high-fat diet and modeling of metabolic syndrome were randomly divided into 4 groups: control, metabolic syndrome (Mets), high intensity interval training (HIIT) and Mets + HIIT. The HIIT program included 5 to 10 intense running on the treadmill with an intensity of 80 to 95% of the maximum speed and in slow running with a speed of 55% of the maximum speed with a zero slope of the treadmill for 8 weeks. Data were analyzed using one-way analysis of variance (ANOVA). The results of one-way analysis of variance showed that there was a difference between the mean expression of MMP-2 and PAI-2 mRNA in adipose tissue of male rats with metabolic syndrome in different groups (P = 0.001). However, HIIT improve this gene after Mets in adipose tissue (p 0.05). It seems that HIIT program improve metabolic syndrome with controlling PAI-2 mRNA and have an anti-inflammatory effect in adipose tissue. However, it need to more studies especially on human sample.
Keywords
high intensity interval training , Metabolic Syndrome , MMP2 , PAI , 1
Journal title
Journal of Exercise Organ Cross Talk
Journal title
Journal of Exercise Organ Cross Talk
Record number
2736760
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