Author/Authors :
Ali ، Shaimaa Hussein Department of Pathological Analysis - College of Science - Al-Qasim Green University , Al-Harbi ، Hussein Jasim Obaid Department of Biology - College of Science - University of Babylon , Alqazzaz ، Ali Mohammad Hussein College of Medicine - University of Babylon
Abstract :
Osteoporosis is not limited to women after menopause. It can also afflict men as well and is a hot issue. Men get osteoporotic fractures around ten years later in life than women, although men’s life expectancy is growing at a quicker rate than that of women. Consequently, males are living longer than women, and when they do, the repercussions are more severe than those experienced by their female counterparts. The aim of our study was to determine the level of CX3CL1, Bone sialoprotein, Gelsolin, Cathepcin K, Vitamin D, Calcium, Phosphorous and Alkaline phosphatase in 100 patients (20 men and 80 women) and 50 as the control group (19 men and 31 women). The results showed that the serum level of CX3CL1, Gelsolin and Cathepcin K increased in female osteoporosis patients and no significant increase was observed in male osteoporosis patients compared with the control group. The results also showed a rise in serum levels of Bone sialoprotein and Alkaline phosphatase in male and female osteoporosis compared with the control group. Further, no significant difference in serum level (vitamin D, Calcium and Phsphorouse) in osteoporosis patientt, both male and female, compared with the control group. In conclusion, the Cathepcin K, Gelsolin and Bone sialoprotein play an essential role in bone metabolism and increase the level in osteoporosis patients.
