Title of article :
The Performances of Conventional Titanium and Silver-Coated Megaprostheses in Non-oncological and Post-oncological Patients: An Analysis of Infection Failures in 142 Patients
Author/Authors :
Sacchetti ، Federico Research performed at the Department of Orthopaedic and Trauma Surger - University of Pisa , Kilian ، Raphael Department of Orthopaedic and Trauma Surgery - University of Pisa , Muratori ، Francesco Department of Orthopaedic and Trauma Surgery - University of Pisa , Cherix ، Stephane Department of Orthopaedic and Trauma Surgery - University of Pisa , Foschi ، Lorenzo Department of Orthopaedic and Trauma Surgery - University of Pisa , Morganti ، Riccardo Department of Orthopaedic and Trauma Surgery - University of Pisa , Campanacci ، Domenico Department of Orthopaedic and Trauma Surgery - University of Pisa Address of the Hospital Careggi University of Florence , Capanna ، Rodolfo Department of Orthopaedic and Trauma Surgery - University of Pisa
Abstract :
Background: Megaprostheses are one of the preferred choices of reconstruction after tumor resection. Periprosthetic joint infections are one of the most serious complications of joint prostheses surgeries. In this study, our aim was to analyze the efficacy of silver-coated megaprostheses in reducing the risk of prosthesis-related infection.Methods: One hundred forty-two patients who had undergone implantation of a mega-endoprosthesis for nonneoplastic or post-neoplastic conditions were included in this retrospective study. The end-point of the survival analysis was the prosthesis failure due to infection. Results: Thirty-eight patients had undergone implantation of a silver-coated megaprosthesis and 104 patients a megaprosthesis without silver coating. The survival analysis showed an overall infection-free survival rate of 82.3% at five years and 61.9% at 10 years. Silver-coated prostheses had an HR of 0.72 (95% CI: 0.26-2.05; P=0.54).Conclusion: Implantation of a silver-coated mega-prosthesis in non-oncological patients did not significantly reduce the risk of prosthesis-related infection.Level of evidence: III
Keywords :
Endoprosthesis , Infection , megaprosthesis , Periprosthetic Infection , Silver , silver , coated
Journal title :
The Archives of Bone and Joint Surgery
Journal title :
The Archives of Bone and Joint Surgery
