Upregulation of SNHG7 and FAIM2 Expression Levels in Chronic Myelogenous Leukemia Patients Compared with Normal Subjects

Background: Chronic myelogenous leukemia (CML), also known as chronic granulocytic leukemia (CGL), is considered a hematological malignancy with a prevalence of 1.9 per 100,000 population. Recent studies have shown the role of SNHGsin proliferation, apoptosis, CML progression, and even drug resistance through interaction with miRNAs. The positive correlation between lncRNA-small nucleus RNA host gene 7 ( SNHG7) and Fas apoptosis inhibitory molecule 2 ( FAIM2) with different cancers has been proved. Objectives: This study investigated the role of SNHG7and FAIM2in CML for the first time and revealed the potential correlation between these genes. Methods: This research was performed with a case-control design. First, the patients were confirmed by using karyotype in addition to molecular and cellular methods. After RNA extraction from white blood cells and cDNA synthesis, gene expression was measured with the use of real-time PCR. Finally, the data were statistically analyzed. Results: The results of this study showed that the expression levels of SNHG7 and FAIM2 were significantly increased in chronic myelogenous leukemia patients compared with normal individuals (P-value 0.001). This increased expression may indicate a potential role for this molecule in the progression and development of this cancer. Conclusions: The current study demonstrates the effective roles of SNHG7 and FAIM2 in the progression of chronic myeloid leukemia, which can be investigated in future studies as biomarkers and potential therapeutic targets.