Evaluation of Lipid Profile, Apo B/ Apo A Ratio and Lpa and its Relationship with Cognitive Disorders in the Older Adults: Birjand Longitudinal Aging Study

Introduction: Accurate and timely diagnosis of mild cognitive disorders is essential to prevent their progression to dementia. This study aimed to determine the relationship among the serum levels of lipid markers of cognitive disorders in older adults in Birjand. Materials and Methods: The community-based cohort study was performed on 1400 older adults population (60 years and older) living in urban and rural areas of Birjand, among whom 242 older adults were selected by multi-stage random sampling; the Mini-Mental State Examination Cognitive Disorders Questionnaire was completed, and five cc of blood samples were taken to assess Triglyceride, Cholesterol, Low density lipoprotein, High-density lipoprotein, lipoprotein a, Apo lipoprotein A, and Apo lipoprotein B. Results: The mean age of participants was 70.6± 6.96 years. 55.4% were women. The level of MMSE was significantly different based on the demographic information. Mean serum levels of Lipid profile, Apo B/ Apo A Ratio, and LP a, were not significantly different from MMSE. Conclusion: The study showed a significant relationship between demographic information and MMSE level, so it can be used to improve the cognitive level of older adults by changing their life situation, marital status, and education. However, the parameters of Lipid profile, Apo B/ Apo A Ratio, and LP a are not used to diagnose cognitive disorders in older adults.