Title of article
Synthesis of Novel 5-Hydrogenphosphonothioate Derivatives of AZT, d4T and ddI
Author/Authors
SUN، Ming نويسنده , , Jin، Ying نويسنده , , Fu، Hua نويسنده , , Zhao، Yu-Fen نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
-115
From page
116
To page
0
Abstract
5ʹ-hydrogenphosphonothioate derivatives of AZT, d4T, and ddI as anti-HIV prodrug candidates were synthesized in 61–76% yields under mild conditions through sequential one-pot reactions, i.e., couple of triethylammonium phosphinate with different alcohols in the presence of pivaloyl chloride (PV-Cl), following oxidation with elemental sulfur and further condensation with AZT, d4T, or ddI in the presence of PV-Cl.
Keywords
Application-production research , prediction , Genetic-fuzzy system , grinding , Power requirement , Surface finish
Journal title
CHEMISTRY LETTERS
Serial Year
2004
Journal title
CHEMISTRY LETTERS
Record number
27405
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