Title of article :
Prevalence and Antimicrobial Resistance Patterns in ESKAPE Pathogens in Iran
Author/Authors :
Armin ، Shahnaz Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Fallah ، Fatemeh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Karimi ، Abdollah Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Shirvani ، Fariba Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Azimi ، Leila Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Almasian Tehrani ، Nasim Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Abdollahi ، Nafiseh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Mobasseri ، Parisa Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Rajabnejad ، Maryam Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Mansour Ghanaiee ، Roxana Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Hoseini-Alfatemi ، Mahsan Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Fahimzad ، Alireza Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Karami ، Najmeh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Tajbakhsh ، Mercedeh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Ghandchi ، Ghazaleh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences , Rafiei Tabatabaei ، Sedigheh Pediatric Infections Research Center, Research Institute of Children’s Health - Shahid Beheshti University of Medical Sciences
Abstract :
Background: The spread of resistant bacteria has caused serious concern worldwide. The spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR) limits the choice of antibiotics, making available antibiotics less e ective. Objectives: This study aimed to investigate resistance patterns to seven global threatening organisms announced by the Centers for Disease Control and Prevention (CDC) for one year in Iran, called ESKAPE bacteria (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.). Methods: Clinical isolates were collected from 10 selective hospitals in nine provinces. Antibiotic susceptibility testing was per-formed according to the Clinical and Laboratory Standards Institute for each bacterium. Results: A total of 5522 bacterial species were considered, of which 30% were ESKAPE. Multidrug-resistant A. baumannii and Staphy-lococcus aureus methicillin-resistant Staphylococcus aureus (MRSA) were the most identified in gram-negative and -positive bacteria, with the frequency of 44% and 39%, respectively. The remaining bacteria, including E. coli, K. pneumoniae, Enterobacter spp. P. aerugi-nosa, and Enterococcus spp., had the frequency of 30%, 32%, 21%, 20%, and 22%, respectively. Conclusions: The determined patterns for the antibiotic resistance of the ESKAPE bacteria can help determine antibiotic steward-ship. Also, the high rates of the ESKAPE bacteria in Iran could be alarming for healthcare centers not to misuse broad-spectrum antibiotics.
Keywords :
ESKAPE , Antibiotic , Resistant Pattern , Iran
Journal title :
Archives of Pediatric Infectious Diseases
Journal title :
Archives of Pediatric Infectious Diseases
