Title of article :
Screening Assessment of the Potential Hazard of Nanomaterials using a Bull Sperm
Author/Authors :
Demetska ، O. Shupyk National Healthcare University of Ukraine , Beliuha ، O. Kundiiev Institute of Occupational Health - National Academy of Medical Sciences of Ukraine , Movchan ، V. Kundiiev Institute of Occupational Health - National Academy of Medical Sciences of Ukraine , Didenko ، M. Kundiiev Institute of Occupational Health - National Academy of Medical Sciences of Ukraine , Riabovol ، V. Bogomolets National Medical University , Patyka ، T. Kundiiev Institute of Occupational Health - National Academy of Medical Sciences of Ukraine , Tsapko ، V. Kundiiev Institute of Occupational Health - National Academy of Medical Sciences of Ukraine , Balia ، A. Graduate School of Pharmaceutical Sciences - Nagoya City University
Abstract :
This paper studied a potential hazard of titanium dioxide nanomaterials in the primary sreening methods on the sample of bull sperm. A method for stabilizing metal nanopowders and their derivatives for biomedical studies is proposed. It was found that the complex of titanium dioxide doped with silver (Ag-TiO2) and nanopowder of titanium dioxide (TiO2) at concentrations of 3 mg/ml initiate pathological changes in the bull sperm: the release of phospholipids as a result of the destruction of membranes and morphological abnormalities (abnormalities of the head, middle part, and tail, as well as the absence of acrosome, etc). The pathological effect of Ag-TiO2 nanocomposite was more pronounced. Doping with silver can increase the toxicity of nanotitanium dioxide, which requires further in-depth experimental studies using different concentrations by in vivo and in vitro methods.
Keywords :
Bull Sperm , Nanomaterials , Screening , Titanium dioxide
Journal title :
International Journal of Nanoscience and Nanotechnology (IJNN)
Journal title :
International Journal of Nanoscience and Nanotechnology (IJNN)
