Title of article :
Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
Author/Authors :
Bakhtiarzadeh ، Fatemeh Department of Physiology - Faculty of Medical Sciences - Tarbiat Modares University , Zare ، Meysam Department of Physiology - Faculty of Medical Sciences - Tarbiat Modares University , Ghasemi ، Zahra Lunenfeld-Tanenbaum Research Institute , Dehghan ، Samaneh Stem cell and Regenerative Medicine Research Center, Eye Research Center, The Five Senses Health institute, Rasool Akram Hospital - Iran University of Medical Sciences , Sadeghin ، Azam Department of Physiology - Faculty of Medical Sciences - Tarbiat Modares University , Joghataei ، Mohammad Taghi Department of Anatomy and Neuroscience - School of Medicine, Cellular and Molecular Research Center - Iran University of Medical Sciences , Ahmadirad ، Nooshin Cellular and Molecular Research Center - Iran University of Medical Sciences
Abstract :
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%-40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature on vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems, and deep brain stimulation (DBS) in animals and epileptic patient with an emphasis on drug-resistant epilepsy.
Keywords :
Drug , resistant epilepsy , Vagus nerve stimulation , Trigeminal nerve stimulation , Responsive stimulation system , Deep brain stimulation
Journal title :
Basic and Clinical Neuroscience
Journal title :
Basic and Clinical Neuroscience
