Title of article :
The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls
Author/Authors :
Fazeli ، Mostafa Department of medical genetic and molecular medicine, Molecular Medicine Group - School of Medicine - mashhad university of medical sciences , Moslem ، Ali Reza Department of Anesthesiology - Faculty of Medicine - Sabzevar University of Medical Sciences , Meshkat ، Zahra Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Timar ، Ameneh Metabolic syndrome Research center - Mashhad University of Medical Sciences , Tabatabaeizadeh ، Amir Clinical Nutrition Department - School of Medicine - Mashhad University of Medical Sciences , Ghazizadeh ، Hamideh Student Research Committee, International UNESCO center for Health Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences , Ghaffarian Zirak ، Roshanak Student Research Committee - Mashhad University of Medical Sciences , Moghbeli ، Meysam Student Research Committee - Mashhad University of Medical Sciences , Boroumand ، Nadia Department of Medical Biochemistry - School of Medicine - Mashhad University of Medical Sciences , jaberi ، Naghme Department of Medical Biochemistry - School of Medicine - Mashhad University of Medical Sciences , Mohammadzadeh ، Mohammad Department of Physiology Pharmacology - Cellular and Molecular Research Center - Sabzevar University of Medical Sciences , Ferns ، Gordon A. Division of Medical Education - Brighton Sussex Medical School , Bahrami-Taghanaki ، Hamid Reza Metabolic syndrome Research center - Mashhad University of Medical Sciences , Ghayour-mobarhan ، Majid Student Research Committee, International UNESCO center for Health Related Basic Sciences and Human Nutrition - Mashhad University of Medical Sciences
Abstract :
Background: Metabolic syndrome (MetS) is characterized by metabolic and anthropometric abnormalities which are associated with an increased risk of cardiovascular disease (CVD). Red blood cell distribution width is a candidate biomarker for CVD. Method: Nine hundred and eighty-eight girls who were between 12 to 18 years old were enrolled. Anthropometric parameters and blood pressure were measured, together with biochemical and hematological variables, using routine measures. International diabetes federation (IDF) criteria were used for the diagnosis of MetS. Result: Some of the demographic parameters such as weight, neck circumference (NC), waist circumference (WC) and hip circumference (HP) were significantly different between the groups with and without MetS, as may be expected. Significantly higher values for red blood cell distribution width (RDW) were observed only in subjects with waist circumference (P= 0.017) and fasting blood glucose levels (P= 0.038). RDW measures were directly associated with MetS status (r=0.076 (P =0.043)), WC (r=0.097 (P =0.016)), and fasting blood glucose (FBG) (r= -0.085 (P =0.037)). It was found that the RDW had specificity and sensitivity for MetS-based IDF criteria 48.01 and 77.78, respectively. RDW related cure area (95% CI) for MetS was reported to be 0.588 (0.380- 0.796). Conclusion: We found that an elevated RDW was associated with the presence of MetS and with some its components; but ROC analysis revealed that a weak specificity in spite of good sensitivity of RDW for MetS, along with a low AUC may make it unusable for the diagnostic prediction of MetS in this population.
Keywords :
Achievement goals , cheating behavior
Journal title :
International Journal of Pediatrics
Journal title :
International Journal of Pediatrics
