Title of article :
Relationship between recurrence pregnancy loss and microRNA expression
Author/Authors :
Yari ، Hadi Human Genetics Division, Medical Biotechnology Department - National Institute of Genetics Engineering and Biotechnology , Mohammadi ، kazhaleh Researcher and lecture assistant at the Medical Laboratory Science Department - Knowledge University , Keshavarz Shahbaz ، Mohammad Ali Human Genetics Division, Medical Biotechnology Department - National Institute of Genetics Engineering and Biotechnology , Esfahani ، Vahid Reza Personalized Medicine Research Center of AmitisGen
Abstract :
The miRNAs produced predominantly in the placenta are probably involved in placental differentiation and maintenance of pregnancy. One of the important functions of miR-126 is its involvement in angiogenesis by enhancing the expression of VEGF. Abnormalities of placental vasculature may result in several gestational complications, including pregnancy loss. The current study compared the expression of miR-126 in the plasma of women with recurrent miscarriages and women with healthy pregnancies by Realtime qRT-PCR. The results indicated that the expression difference of miR-21 between the pregnant patients and the controls was statistically significant (p =0.002). This microRNA can be used as a biomarker in diagnosis and progression.
Keywords :
MicroRNA , Recurrent Pregnancy Loss , Gene expression , Realtime qRT , PCR
Journal title :
Personalized Medicine Journal
Journal title :
Personalized Medicine Journal
